Holders Liverpool are staring down the barrel of a Champions League exit against Benfica and Real Madrid [Images] face a similar fate at Arsenal [Images] on Wednesday.

Liverpool and Real need to overturn 1-0 deficits in their knockout round second leg ties, as do PSV Eindhoven if they are to reach the quarter-finals at the Stade Gerland against Olympique Lyon.

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AC Milan can afford to sit back on their away goal after drawing 1-1 at Bayern Munich, though expectations at San Siro will have grown with five consecutive wins in Serie A and a hatful of goals from Filippo Inzaghi.

Liverpool's problem is that they need to find goals at a time of drought.

Rafael Benitez's men famously scored three in the second half of the 2005 final against Milan but have only managed four in their last eight games. They have not scored twice in any match since January and need to find the net at Anfield.

Benfica, who knocked out Liverpool's old rivals Manchester United [Images] in the group stages, are likely to bide their time and wait for a chance to hit Benitez's men on the break.

Real Madrid will be looking to impress their new club president Fernando Martin at Highbury.

Ronaldo [Images] is expected to lead the charge, supported by Zinedine Zidane [Images] and David Beckham [Images] on the flanks, with Robinho available to add a further attacking threat from midfield.

Bayern's Dutch striker Roy Makaay will be the main danger man for Milan, who will be without their combative midfielder Gennaro Gattuso [Images] through suspension.

Though the odds are against them, Bayern keeper Oliver Kahn is already convinced of the outcome. "I am absolutely certain we will qualify," he told reporters.

Lyon face a PSV side who have yet to score an away goal in the Champions League but who need to score at least twice to go through without resorting to a penalty shoot out.

Like Real with Ronaldo, Julio Baptista and Robinho, Lyon will look to Brazilians for inspiration in striker Fred and attacking midfielder Juninho, their predatory and brilliant free kick taker.