Manchester United [Images] striker Ruud van Nistelrooy [Images] left Old Trafford on Sunday before his side's Premier League game against Charlton Athletic.
"Ruud van Nistelrooy has gone home and will not play against Charlton," United said in a statement.
"We are not prepared to say anything as we are concentrating on the game against Charlton."
Speculation has surrounded the Dutchman's future at the club with the 29-year-old apparently falling out of favour with Alex Ferguson in recent months.
Frenchman Louis Saha and teenage Italian striker Giuseppe Rossi start up front against Charlton. Second-placed United can secure the second automatic Champions League place with a win over the London [Images] side.
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